A collaboration between the University of California, San Diego (UCSD) and the The Scripps Research Institute (TSRI) has recently published a high-resolution single-particle cryo-EM reconstruction of the GroEL chaperonin at 6.1 Å-resolution, based on images acquired using the DE-12 Camera System from Direct Electron.  The results show significant improvement compared to a similar reconstruction from CCD images.

Initial evaluation of a direct detection device detector for single particle cryo-electron microscopy
Milazzo AC, Cheng A, Moeller A, Lyumkis D, Jacovetty E, Polukas J, Ellisman MH, Xuong NH, Carragher B, Potter CS
Journal of Structural Biology
PubMed ID: 21933715

The DE-12 Camera System uses the revolutionary Direct Detection Device (DDD) sensor from Direct Electron to capture digital images of high-energy electrons directly, resulting in unprecedented sensitivity and resolution.  The published results using the DE-12 prove its effectiveness for routine use in electron cryo-microscopy.