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Material
Science

Dynamic Range

DE cameras offer the ultimate resolution, sensitivity, and the largest available field-of-view to optimize low-dose applications such as single particle cryo-EM and cryo-tomography. Collect high-quality data quickly, use our powerful movie-mode processing algorithms, and generate stunning and reliable 3D reconstructions.

material-science
APPLICATION OVERVIEW

Unprecedented Resolution &
Sensitivity in Materials

By eliminating the scintillator, our direct detection cameras provide unprecedented resolution and sensitivity. But is that level of resolution truly necessary for materials science? Absolutely! Many materials science applications rely on the ability of investigators to unambiguously detect high-resolution features in an image. Using a poor camera and blurry images makes the delineation of features ambiguous, and (even worse) many high resolution features may not be detectable at all.

Electron holography offers the unique capability to characterize the three-dimensional structure of TEM specimens, since observed phase changes (which are now disentangled from amplitude information in a hologram) is directly proportional to the local thickness of the material through which the electron beam is passing.

Until recently, acquiring electron holograms always has been a technological challenge. On film, both the non-linearity and the modulation transfer function (MTF) impacted the quality of the hologram, as higher order sidebands are generated and higher frequencies are dampened. Although digital cameras are very linear up to at least 70% to their saturation, the MTF of almost every camera on the market drops to around 10% or below at the Nyquist limit and for sampling rates (pixels per interference fringe) s < 10, most MTFs are already below 50% at the location of the sideband.

As a compromise, electron holograms are recorded highly oversampled and the images obtained from the holograms are often downsized as they contain a lot of empty information due to the oversampling. Our DE-Series Cameras are a revolutionary advancement for electron holography, approaching the theoretical limits of an ideal detector for this technique. The linearity, MTF, and array size of our cameras produce high-quality holograms without significant oversampling, to deliver a dramatically larger field-of-view. Additionally, the high sensitivity and per-electron signal-to-noise ratio of our direct detection cameras enable low-dose electron holography for the first time. This critical advancement allows researchers to probe the structure of specimens in an unperturbed state, without the deleterious effects of radiation damage.

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With guidance from our team of Ph.D microscopists