Direct Electron is proud to sponsor and participate in the NCMI Workshop on Single Particle Reconstruction, Structural Variability and Modeling on October 30 – November 2, 2015, in Houston, TX. The workshop will include a mix of theory talks and tutorial sessions. The workshop will begin on day 1 with introductory talks and a tutorial on EMAN2.1. Days 2 and 3 will be devoted to the issue of both compositional and conformational heterogeneity, from multiple perspectives studying the approaches used in 3 different software packages: EMAN2.1, Relion, and Sparx. While variability is often one of the greatest barriers to high resolution structure determination, it also represents a great opportunity to learn more about how complex macromolecular machines function in solution. On the final day of the workshop we will discuss modeling across all resolution ranges, from low resolution docking to de-novo model building at high resolution. For more details, visit http://ncmi.bcm.edu/ncmi/events/workshops/workshops_145.