NIH Announces New Regional Consortia for High-Resolution Cryo-EM

Posted on October 3, 2014 in News

For cryo-EM laboratories in the USA, the NIH just made an exciting announcement…

Today, the National Institute of General Medical Sciences (NIGMS) of the US National Institutes of Health (NIH) posted a request for applications for “Regional Consortia for High Resolution Cryoelectron Microscopy (U24).” The purpose of this funding opportunity is to provide regional access for electron cryo-microscopy (cryo-EM) laboratories to state-of-the-art data collection capabilities, specifically including direct electron detection cameras.

Each funded consortium will coordinate between its members to share facilities and resources for direct electron detection. Consortia will consist of a host institution which already has a modern high-performing cryo-EM installation and proven capabilities for high-resolution data collection, partnered with regional participating institutions. This funding will support surplus capacity for cryo-EM data collection (infrastructure and services) at the host institution and make it available as a resource for the participating regional institutions.

In addition to funding to support infrastructure and services, this FOA can help fund acquisition of direct detection equipment.

Direct Electron’s DE-series cameras are absolutely ideal for such regional centers.

Such centers need to demonstrate the high performance of direct detection together with accessibility to a wide range of cryo-EM experiments. DE cameras deliver exceptional performance for a broad range of exposure rates, magnifications, and imaging conditions.

Additionally, because this funding requires the host cryo-EM lab to suddenly support a much larger base of users, having a camera that provides high-throughput, high-efficiency imaging will be critical to the success of each consortium. Our DE-64 Camera (8k x 8k) has by far the largest field-of-view of any direct detection camera, giving users an enormous amount of data per image. This dramatically reduces the burden on high-demand instrumentation. For example, a requires four days of data collection using a standard 4k x 4k direct detector would only require one day with a DE-64!

If you would like to discuss how we can help you with this exciting new funding opportunity, please contact us.

A Letter of Intent is due by December 27, 2014, and the Application is due January 27, 2015. Because the restricted scope and special instruction for this FOA, potential applicants are strongly advised to discuss their plans with the designated NIH Scientific/Research contact, Paula Flicker.

For more information, see the NIH announcement at: